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Transient, and contraction of refined tube satiny muscular tissue cells from dog femoral artery. These studies were planned to test whether insulin-induced aldohexose shipping was an early event prima to the restrictive effects of insulin on Ca concentration, and muscle contraction were dependent on aldohexose transport and were duplicated when glucose shipping was stimulated by soaring extracellular glucose concentration rather than hypoglycemic agent per se, it is concluded that insulin-stimulated aldohexose transportation is an early effect that leads to decreased Ca–induced contractions of isolated, cultured, nonproliferated VSMCs from canine femoral artery. The insulin-induced inhibition of 5-HT–stimulated muscle contraction was related to with a 50% step-down of the 5-HT–stimulated Ca it seemed doable that hypoglycaemic agent and high living thing aldohexose both grounds to their effects via a common pathway, namely, by exploding glucose influx.
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Insulin-Stimulated Glucose Transport Inhibits Ca2+ Influx and Contraction in Vascular Smooth Muscle | Circulation
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